Advances in Primary Central Nervous System Lymphoma

作者：Patrick Lauren B; Mohile Nimish A

来源：Current Oncology Reports, 2015, 17(12): 60.

DOI：10.1007/s11912-015-0483-8

• Primary central nervous system lymphoma
• Diffuse large B cell lymphoma
• Ocular lymphoma
• Leptomeningeal metastases
• Bone marrow transplant
• Leukoencephalopathy
• High-dose methotrexate

Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma that is limited to the CNS. Although novel imaging techniques aid in discriminating lymphoma from other brain tumors, definitive diagnosis requires brain biopsy, vitreoretinal biopsy, or cerebrospinal fluid analysis. Survival rates in clinical studies have improved over the past 20 years due to the addition of high-dose methotrexate-based chemotherapy regimens to whole-brain radiotherapy. Long-term survival, however, is complicated by clinically devastating delayed neurotoxicity. Newer regimens are attempting to reduce or eliminate radiotherapy from first-line treatment with chemotherapy dose intensification. Significant advances have also been made in the fields of pathobiology and treatment, with more targeted treatments on the horizon. The rarity of the disease makes conducting of prospective clinical trials challenging, requiring collaborative efforts between institutions. This review highlights recent advances in the biology, detection, and treatment of PCNSL in immunocompetent patients.

• 出版日期2015-12