North American ginseng (Panax quinquefolius) suppresses beta-adrenergic-dependent signalling, hypertrophy, and cardiac dysfunction

作者：Tang Xilan; Gan Xiaohong Tracey; Rajapurohitam Venkatesh; Huang Cathy Xiaoling; Xue Jenny; Lui Edmund M K; Karmazyn Morris^*

来源：Canadian Journal of Physiology and Pharmacology, 2016, 94(12): 1325-1335.

DOI：10.1139/cjpp-2016-0337

• ginseng
• isoproterenol
• heart failure
• cardiomyocyte hypertrophy
• beta-adrenergic signaling
• PKA
• CREB

There is increasing evidence for a beneficial effect of ginseng on cardiac pathology. Here, we determined whether North American ginseng can modulate the deleterious effects of the beta-adrenoceptor agonist isoproterenol on cardiac hypertrophy and function using in vitro and in vivo approaches. Isoproterenol was administered for 2 weeks at either 25 mg/kg per day or 50 mg/kg per day (ISO25 or ISO50) via a subcutaneously implanted osmotic mini-pump to either control rats or those receiving ginseng (0.9 g/L in the drinking water ad libitum). Isoproterenol produced time-and dose-dependent left ventricular dysfunction, although these effects were attenuated by ginseng. Improved cardiac functions were associated with reduced heart masses, as well as prevention in the upregulation of the hypertrophy-related fetal gene expression. Lung masses were similarly attenuated, suggesting reduced pulmonary congestion. In in vitro studies, ginseng (10 mu g/mL) completely suppressed the hypertrophic response to 1 mu mol/L isoproterenol in terms of myocyte surface area, as well as reduction in the upregulation of fetal gene expression. These effects were associated with attenuation in both protein kinase A and cAMP response element-binding protein phosphorylation. Ginseng attenuates adverse cardiac adrenergic responses and, therefore, may be an effective therapy to reduce hypertrophy and heart failure associated with excessive catecholamine production.

• 出版日期2016-12