An Embedded Deep Brain Stimulator for Biphasic Chronic Experiments in Freely Moving Rodents

作者：Koelbl Florian; N'Kaoua Gilles; Naudet Frederic; Berthier Florent^*; Faggiani Emilie; Renaud Sylvie; Benazzouz Abdelhamid^*; Lewis Noelle

来源：IEEE Transactions on Biomedical Circuits and Systems, 2016, 10(1): 72-84.

DOI：10.1109/TBCAS.2014.2368788

• Biomedical engineering
• deep brain stimulation
• electrode driver
• implants
• low power

This paper describes a Deep Brain Stimulation device, portable, for chronic experiments on rodents in the context of Parkinson's disease. Our goal is to equip the animal with a device that mimics the human therapeutic conditions. It implies to respect a set of properties such as bilateral current-mode and chargebalanced stimulation, as well as programmability, low power consumption and re-usability to finally reach a suitable weight for long-term experiments. After the analysis of the solutions found in the literature, the full design of the device is explained. First, the stimulation front-end circuit driven by a processor unit, then the choice of supply sources which is a critical point for the weight and life-time of our system. Our low cost system has been realized using commercial discrete components and the overall power consumption was minimized. We achieved 6 days of maximal current stimulation with the chosen battery for a weight of 13.8g. Finally, the device was carried out in vivo on rats during a 3 weeks experiment as the used implantation technique allows battery changing. This experiment also permits to emphasize the mechanical aspects including the packaging and electrodes holding.

• 出版日期2016-2
• 单位中国地震局