Nonblinking and Nonbleaching Upconverting Nanoparticles as an Optical Imaging Nanoprobe and T1 Magnetic Resonance Imaging Contrast Agent

作者：Park Yong Il; Kim Jeong Hyun; Lee Kang Taek; Jeon Ki Seok; Bin Na Hyon; Yu Jung Ho; Kim Hyung Min; Lee Nohyun; Choi Seung Hong; Baik Sung Il; Kim Hyoungsu; Park Seung Pyo; Park Beom Jin; Kim Young Woon; Lee Sung Ho; Yoon Soo Young; Song In Chan; Moon Woo Kyung; Suh Yung Doug^*; Hyeon Taeghwan

来源：Advanced Materials, 2009, 21(44): 4467-+.

DOI：10.1002/adma.200901356

Core/shell upconverting nanoparticles (UCNPs) of NaGdF(4):Er(3+), Yb(3+)/NaGdF(4) (see figure) are shown to serve as a multimodal imaging probe that works for both background-free optical imaging and magnetic resonance imaging (MRI). The nonblinking and nonbleaching properties of UCNPs can contribute to minimization of possible artifacts in long-term imaging experiments. Owing to Gd(3+) ions in the host matrix, contrast is enhanced in T(1)-weighted MRI.

• 出版日期2009-11-26