GnRH agonist triggering affects the kinetics of embryo development: a comparative study

作者：Gurbuz Ali Sami^*; Gode Funda; Uzman Mehmet Sukru; Ince Betul; Kaya Melek; Ozcimen Necati; Ozcimen Emel Ebru; Acar Ali

来源：Journal of Ovarian Research, 2016, 9(1): 22.

DOI：10.1186/s13048-016-0229-8

• Agonist trigger
• Oocyte
• Embryo quality
• Time lapse
• Morphokinetic

Background: To evaluate the effects of an ovulation triggering agent, human chorionic gonadotropin (hCG), versus a gonadotropin-releasing hormone agonist (GnRHa) on early embryo development in vitro using a time-lapse system.
Methods: Retrospective analysis of a prospectively collected database. A total of 739 embryos from 152 infertile couples undergoing intracytoplasmic sperm injection cycles.
Interventions : Embryo culture in a time-lapse incubator (EmbryoScope, Vitrolife, Goteborg, Sweden). Main Outcome Measures: Embryo morphokinetic parameters.
Results: In the 152 women, 252 embryos were derived from GnRHa-triggered cycles compared with 487 embryos derived from hCG-triggered cycles. Time-lapse analysis revealed that embryos from cycles triggered by a GnRHa cleaved faster than embryos derived from hCG-triggered cycles.
Conclusion: Triggering with a GnRHa in in vitro fertilization cycles affects embryo kinetics.

• 出版日期2016-4-8