NO releasing diazeniumdiolates and targeting NO releasing materials

作者：Gao Qun^*; Wan Ajun

来源：Progress in Chemistry, 2006, 18(9): 1101-1109.

• nitric oxide
• NO donor
• diazeniumdiolates
• nucleophiles
• targeting NO release

Chemical structures and properties of diazeniumdiolates that make them so excellent for designing materials capable of targeting reliable and controllable fluxes of bioactive NO have become one of the forefronts and highlights of novel NO donors. The toxicity and poor biocompatibility of the nucleophile (polyamines) and the formation of potentially carcinogenic nitrosoamine are the problems associated with its successful clinical application. Recent research progress on targeting nitric oxide releasing materials is reviewed, basing on the three strategies of delivering NO specifically to a targeted site, including polymer-based diazeniumdiolates, enzyme activated diazeniumdiolates. and photosensitive diazeniumdiolates.

• 出版日期2006-9
• 单位上海交通大学