AN EFFICIENT MICROWAVE-ASSISTED MULTI-COMPONENT SYNTHESIS OF RHODANINE DERIVATIVES

作者：Jadhav Santosh A; Shioorkar Mahesh G; Chavan Omprakash S; Sarkate Aniket P; Farooqui Mazahar; Shinde Devanand B; Pardeshi Rajendra K^*

来源：Indian Journal of Heterocyclic Chemistry, 2016, 25(3-4): 201-207.

• rhodanine
• aldehyde
• methyl iodide
• tri-ethyl amine
• acetonitrile
• microwave-assisted

Acetonitrile and triethyl amine has been identified as green solvent and base catalyst or the 1 multicomponent synthesis of 5-arylidine-2-(methylthio)-thiazolones (4) in good to excellent yields (83-97%) starting from rhodanine (1), substituted aryl aldehyde (2) and iodomethane (3) by using microwave irradiation method. Present protocol offers advantages of short reaction time, simple workup, and high yields of products.

• 出版日期2016-6