FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-beta-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES

作者：Rogel Cristian; Mendoza Nestor; Troncoso Jose; Gonzalez Javier; Von Plessing Carlos

来源：Journal of the Chilean Chemical Society, 2011, 56(1): 574-579.

DOI：10.4067/S0717-97072011000100011

The interaction between Florfenicol (FF), Hydroxypropyl-beta-cyclodextrin (HP beta CD), and Chitosan (CH) has been studied in aqueous solution and in solid state, using 3 preparation methods (Evaporation, Lyophilization, Spray Drying) for HP beta CD and only Spray Drying for Chitosan. The phase solubility study shows that the complex is formed with 1:1 stoichiometry and 181,4 M-1 as the association constant. The analysis with Differential Scanning Calorimetry (DSC) together with Scanning Electron Microscopy (SEM) micrographs evidenced the formation of inclusion complexes, mainly with the product prepared by spray drying. Studies in vitro showed that FF solubility was improved almost to double, with a better dissolution profile exhibited by the product prepared by spray drying.

• 出版日期2011-3