Alpha-Fetoprotein: The Predictor of Microvascular Invasion in Solitary Small Hepatocellular Carcinoma and Criterion for Anatomic or Non-Anatomic Hepatic Resection

作者：Fan, Lu-Feng; Zhao, Wen-Chao; Yang, Ning; Yang, Guang-Shun^*

来源：Hepato-Gastroenterology, 2013, 60(124): 825-836.

DOI：10.5754/hge121039

• Hepatocellular carcinoma
• Anatomic resection
• Non-anatomic resection
• Microvascular invasion
• Alpha-fetoprotein
• Solitary

Background/Aims: This study aimed to identify the preoperative predictors of microvascular invasion (MVI) in solitary small hepatocellular carcinoma (HCC) and evaluate their application in surgical treatment. Methodology: We retrospectively analyzed 161 patients with solitary small HCC who underwent curative hepatic resection. Overall and disease-free survival rates were calculated by Kaplan-Meier method and compared by log-rank test. The independent predictors were identified by Cox proportional hazards model. Results: MVI was an independent predictor of both overall and disease-free survival. In 51 patients with MVI, anatomic resection achieved better survival than non-anatomic resection. However, anatomic resection and non-anatomic resection brought similar survival in patients without MVI. Alpha-fetoprotein (AFP) was identified as the unique predictor of MVI (HR=2.773, p=0.004). Anatomic resection achieved better survival outcome than non-anatomic resection when AFP >100 mu g/L (5-year overall survival rate: 85% vs. 55%, p=0.024; 5-year disease-free survival rate: 37% vs. 21%, p=0.025), while there was no statistical survival difference between anatomic and non-anatomic resection when AFP <= 100 mu g/L (5-year overall survival rate: 85% vs. 76%, p=0.838; 5-year disease-free survival rate: 48% vs. 49%, p=0.921). Conclusions: Compared with non-anatomic resection, anatomic hepatic resection improves overall and disease-free survival of solitary small HCC patients with AFP >100 mu g/L.

• 出版日期2013-6
• 单位中国人民解放军第二军医大学; 中国人民解放军总医院