A novel polyurethane/cellulose fibrous scaffold for cardiac tissue engineering

作者：Chen Po Hsuen; Liao Hsueh Chung; Hsu Sheng Hao; Chen Rung Shu; Wu Ming Chung; Yang Yi Fan; Wu Chau Chung; Chen Min Huey; Su Wei Fang^*

来源：RSC Advances, 2015, 5(9): 6932-6939.

DOI：10.1039/c4ra12486c

The present work demonstrates a biomimetic electrospun scaffold based on polyurethane (PU) and ethyl cellulose (EC), featuring uniform fibrous nanostructures and three dimensional porous networks. The relationship between processing conditions and fibrous nanostructures is established which guides the rational processing with tunable fiber diameters. Additionally, the developed scaffold template reveals biocompatibility in retention and proliferation of cardiac myoblast H9C2 cells. The high mechanical strength of the PU/EC scaffolds enables the processing and handling of an ultrathin patch. Their elastomeric characteristics revealed the compatibility between the patch and contractile tissues. Furthermore, anisotropic PU/EC scaffolds with aligned nanofibers were successfully fabricated, exhibiting higher mechanical strength and essential characteristics for the survival and function of cardiac cells with native anisotropy. This work demonstrates a bioengineered PU/EC fibrous scaffold with uniform nanostructural webs and provides insight into the relationships between processing control, nanostructures and associated properties, with promising potential in cardiac tissue engineering.

• 出版日期2015
• 单位长春大学