AN ALTERNATIVE PREPARATION OF PYRAZOLO-PYRIDINE DERIVATIVES IN IONIC LIQUID AND COMPARISON STUDY ON THE REACTIVITY OF THIOAMIDE AND AMIDE GROUP

作者：Zhang, Xin-Ying^*; Li, Xiao-Yan; Fan, Xue-Sen; Wang, Xia; Qu, Gui-Rong; Wang, Jian-Ji

来源：Heterocycles, 2008, 75(12): 3065-3075.

• Ionic Liquid
• Pyrazolo[3,4-b]pyridine
• Pyrazolo[3,4-b]pyridin-6-one
• Arylidenecyanothioacetamide
• Arylidenecyanoacetamide

A novel and efficient preparation of pyrazolo[3,4-b]pyridine (5) and pyrazolo[3,4-b]pyridin-6-one (8) derivatives from the condensation of arylidenecyanothioacetamide (1) or arylidenecyanoacetamide (7) with 5-amino3-methyl-1-phenylpyrazole (4) in [bmim]BF4 is reported for the first time. The mechanism for the formation of 5 from I and 4, or 8 from 7 and 4, and the comparison between the reactivity of thioamide group versus amide group are briefly discussed.

• 出版日期2008-12-1
• 单位河南师范大学