Hereditary isolated ossicular anomalies in two generations of patients

作者：Nakanishi Hiroshi^*; Mizuta Kunihiro; Hamada Noboru; Iwasaki Satoshi; Mineta Hiroyuki

来源：Auris Nasus Larynx, 2011, 38(1): 114-118.

DOI：10.1016/j.anl.2010.06.003

• Ossicular anomaly
• Conductive hearing loss
• Heredity

We present herein a report of an isolated form of ossicular anomaly that affected two generations of patients. Two female patients, a mother and daughter, were admitted with complaints of conductive hearing loss, with no other anomalies and no history of ear infection. Surgical exploration revealed identical ossicular anomalies: the complete absence of the long process of the incus and fixation of the stapes. This anomaly can be considered to have been inherited in an autosomal-dominant or X-linked-dominant manner. To date, two reports have described isolated forms of congenital ossicular anomalies. Our findings suggest that isolated congenital anomalies can be inherited.

• 出版日期2011-2