Analysis of CD8+ CD28- T-suppressor cells in living donor liver transplant recipients

作者：Lin, Yi-Xin; Wang, Lan-Lan; Yan, Lu-Nan^*; Cai, Pei; Li, Bo; Wen, Tian-Fu; Zeng, Yong

来源：Hepatobiliary and Pancreatic Diseases International, 2009, 8(3): 241-246.

• T-suppressor cells
• CD8-positive
• living donor
• liver transplantation
• clinical analysis

BACKGROUND: Human CD8(+) CD28(-) T-suppressor (Ts) cells have been considered to indicate a reduced need for immunosuppression in pediatric liver-intestine transplant recipients and recipients of deceased heart-kidney transplants. However, in adult-to-adult living donor liver transplantation (A-A LDLT) little information is available and the clinical significance is still unknown. @@@ METHODS: Flow cytometry was used to detect the population of CD8(+) CD28(-) Ts cells present in peripheral blood in A-A LDLT recipients (n=31), patients with end-stage liver disease (n=24) and healthy controls (n=19). Meanwhile, we tested the graft function and trough levels of immunosuppression in recipients. The clinical and follow-up data of 31 transplant recipients were analyzed. @@@ RESULTS: Compared with diseased controls (P=0.007) and healthy individuals (P=0.000), a notable expansion of CD8(+) CD28(-) Ts cells was found in recipients of A-A LDLT. This was associated with graft function, levels of immunosuppression and rejection episodes. @@@ CONCLUSIONS: To monitor the CD8(+) CD28(-) Ts cells levels is important to evaluate the immune state of recipients. Meanwhile, it is also important to promote expansion of CD8(+) CD28(-) Ts cells in recipients of A-A LDLT, not only to sustain good graft function and decrease the dosage of immunosuppressants, but also to reduce the occurrence of rejection. (Hepatobiliary Pancreat Dis Int 2009; 8: 241-246)

• 出版日期2009-6
• 单位四川大学