Anti-oxidant, anti-fungal and anti-leishmanial activities of novel 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones

作者:Hussain Tanvir; Siddiqui Hamid Latif*; Zia ur Rehman Muhammad; Yasinzai Muhammad Masoom; Parvez Masood
来源:European Journal of Medicinal Chemistry, 2009, 44(11): 4654-4660.
DOI:10.1016/j.ejmech.2009.06.038

摘要

A series of new 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones were synthesized by the condensation of various acetophenones with 4-(1H-imidazol-1-yl) benzaldehyde which was itself prepared by the N-arylation of imidazole using hexadecyltrimethylammonium bromide as catalyst for the first time. All the synthesized compounds were subjected to preliminary evaluation for their anti-leishmanial, anti-oxidant and anti-fungal activities. Few of the synthesized compounds showed significant activities.

  • 出版日期2009-11