Association between IL28B polymorphism, TNF and biomarkers of insulin resistance in chronic hepatitis C-related insulin resistance

作者：Lemoine M^*; Chevaliez S; Bastard J P; Fartoux L; Chazouilleres O; Capeau J; Pawlotsky J M; Serfaty L

来源：Journal of Viral Hepatitis, 2015, 22(11): 890-896.

DOI：10.1111/jvh.12408

• chronic hepatitis C
• hepatitis C virus
• IL28B
• insulin resistance
• leptin
• adiponectin
• tumour necrosis factor alpha

TNF has been shown to play a role in hepatitis C virus (HCV)-induced insulin resistance (IR). Polymorphism of the IL28B gene that encodes IFN-lambda 3 may be associated with IR through modulation of TNF. The aim of this study was to investigate the relationship between IL28B rs12979860 genotype, the level of TNF activation and the degree of IR in patients with chronic hepatitis C. One hundred and thirty-three nondiabetic genotype 1 HCV-infected patients with biopsy proven noncirrhotic hepatitis C were investigated for IR (using HOMA index), IL28B rs12979860 genotype and fasting circulating levels of soluble receptor 1 of TNF (sTNFR1) and adipokines: leptin, adiponectin and IL-6. The HOMA-IR was positively correlated with serum levels of leptin (r=0.35, P<0.0001) and sTNFR1 (r=0.35, P<0.0001) but not with IL-6 or adiponectin. IL28B rs12979860 CC genotype was observed in 35% patients. Genotype CC and nongenotype CC patients were similar in terms of HOMA-IR (means 1.6 +/- 0.9 vs 1.7 +/- 1.4) and had similar circulating levels of sTNFR1 and adipokines. Independent factors associated with IR were ferritin (OR=1.002, P=0.02), leptin (OR=1.06, P=0.02) and sTNFR1 (OR=7.9, P=0.04). This study suggests that in nondiabetic, noncirrhotic, HCV genotype 1-infected patients, there is no relationship between IL28B rs12979860 genotype and HOMA-IR or sTNFR1 level. HCV-related IR may be mediated through TNF independent of IL28B genotype.

• 出版日期2015-11