Systemic inflammation is associated with the density of immune cells in the tumor microenvironment of gastric cancer

作者：Choi Yeonjoo; Kim Jin Won; Nam Kyung Han; Han Song Hee; Kim Ji Won; Ahn Sang Hoon; Park Do Joong; Lee Keun Wook; Lee Hye Seung; Kim Hyung Ho

来源：Gastric Cancer, 2017, 20(4): 602-611.

DOI：10.1007/s10120-016-0642-0

• Neutrophil-lymphocyte ratio
• Prognostic nutritional index
• Immune cell
• Tumor microenvironment
• Gastric cancer

The neutrophil-lymphocyte ratio (NLR) and the prognostic nutritional index (PNI) are markers of systemic inflammation known to be useful prognostic indicators of malignancy. However, little evidence has defined the influence of inflammation on the tumor microenvironment.
Two hundred eighty-eight patients who underwent curative surgery for gastric cancer were included. Preoperative peripheral blood samples were used to analyze the NLR and PNI. The optimal cutoff levels for the NLR and PNI were defined by receiver operating characteristic curve analysis for survival (NLR = 2.7, PNI = 47.7). The densities of specific immune cells (CD3(+), CD4(+), CD8(+)) within the tumor microenvironment were measured in tumor microarrays by immunohistochemical analysis.
Two hundred thirty-five patients (81.6 %) had a low NLR and 53 patients (18.4 %) had a high NLR. One hundred seventeen patients (40.6 %) had a low PNI and 171 patients (59.4 %) had a high PNI. CD3(+) and CD8(+) immune cell density were not associated with the NLR and PNI. However, in the high-NLR group compared with the low-NLR group, CD4(+) immune cell density was significantly decreased (P < 0.001). Similarly, the density of CD4(+) immune cells was also significantly decreased in the low-PNI group compared with the high-PNI group (P = 0.007). A high NLR and a low PNI were correlated with worse overall survival in multivariate analysis (P = 0.028 and P = 0.002 respectively).
The NLR and PNI are associated with the density of CD4(+) immune cells in the tumor microenvironment, which leads to prognostic values of systemic inflammation in gastric cancer.

• 出版日期2017-7