A CRTCal Link between Energy and Life Span

作者：Brunet Anne^*

来源：Cell Metabolism, 2011, 13(4): 358-360.

DOI：10.1016/j.cmet.2011.03.012

Cutting down calories prolongs life, but how this works remains largely unknown. A recent study in Nature (Mair et al., 2011) shows that life span extension triggered by the energy-sensing protein kinase AMPK is mediated by an evolutionarily conserved transcriptional circuit involving CRTC-1 and CREB.

• 出版日期2011-4-6