Unique features of DNA replication in mitochondria: A functional and evolutionary perspective

作者：Holt Ian J^*; Jacobs Howard T

来源：BioEssays, 2014, 36(11): 1024-1031.

DOI：10.1002/bies.201400052

• DNA
• double strand breaks
• fragile sites
• mitochondria
• mitochondrial DNA
• replication
• single strand breaks

Last year, we reported a new mechanism of DNA replication in mammals. It occurs inside mitochondria and entails the use of processed transcripts, termed bootlaces, which hybridize with the displaced parental strand as the replication fork advances. Here we discuss possible reasons why such an unusual mechanism of DNA replication might have evolved. The bootlace mechanism can minimize the occurrence and impact of single-strand breaks that would otherwise threaten genome stability. Furthermore, by providing an implicit mismatch recognition system, it should limit the occurrence of replication-dependent deletions and insertions, and defend against invading elements. Such a mechanism may also limit attempts to manipulate the mammalian mitochondrial genome.

• 出版日期2014-11
• 单位河北医科大学