Anti-apoptotic effects of decyl gallate on the induction of apoptosis in A549 pneumocytes by Paracoccidioides brasiliensis gp43

作者:Bernardi Thais; da Silva Julhiany de Fatima; Vicentin Juliana; de Oliveira Haroldo Cesar; Assato Patricia Akemi; Marcos Caroline Maria; Alves de Paula e Silva Ana Carolina; Moraes da Silva Rosangela Aparecida; Regasini Luis Octavio; Siqueira Silva Dulce Helena; Bolzani Vanderlan da Silva; Fusco Almeida Ana Marisa; Soares Mendes Giannini Maria Jose
来源:Medical Mycology, 2017, 55(8): 890-894.
DOI:10.1093/mmy/myx013

摘要

Apoptosis is considered an escapemechanism from the host immune system for the fungus Paracoccidioides spp, and it serves as a vehicle for entry into macrophages without stimulating microbicidal activities. Recently, gp43 of P. brasiliensis was demonstrated to be involved in this process. Therefore, as a new therapeutic alternative, it is very important to study compounds that could reduce the modulation of the induction of apoptosis caused by this fungus. Decyl gallate (G14) is a known antifungal compound, and we decided to investigate its anti-apoptotic properties. Our results demonstrate that G14 was effective against apoptosis induced by gp43, as observed in epithelial cells, and led to a reduction in DNA damage, Bak down-regulation and Bcl-2 up-regulation. Together, these data show that G14 presents promising anti-apoptotic activity.

  • 出版日期2017-11
  • 单位Univ Estadual Paulista