Limited miR-17-92 overexpression drives hematologic malignancies

作者：Danielsona Laura S; Reavie Linsey; Coussens Marc; Davalos Veronica; Castillo Martin Mireia; Guijarro Maria V; Coffre Maryaline; Cordon Cardo Carlos; Aifantis Iannis; Ibrahim Sherif; Liu Cynthia; Koralov Sergei B^*; Hernando Eva

来源：Leukemia Research, 2015, 39(3): 335-341.

DOI：10.1016/j.leukres.2014.12.002

• miR-17-92
• Mouse model
• Lymphoma

The overexpression of microRNA cluster miR-17-92 has been implicated in development of solid tumors and hematological malignancies. The role of miR-17-92 in lymphomagenesis has been extensively investigated; however, because of the developmental defects caused by miR-17-92 dysregulation, its ability to drive tumorigenesis has remained undetermined until recently. Here we demonstrate that overexpression of miR-17-92 in a limited number of hematopoietic cells is sufficient to cause B cell malignancies. In sum, our study provides a novel and physiologically relevant model that exposes the potent ability of miR-17-92 to act as a driver of tumorigenesis.

• 出版日期2015-3