sp(3)C-H bond alkylation of ketones with alkenes via ruthenium(II) catalysed dehydrogenation of alcohols

作者:Li, Bin*; Darcel, Christophe; Dixneuf, Pierre H
来源:Chemical communications, 2014, 50(45): 5970-5972.
DOI:10.1039/c4cc00931b

摘要

The sp(3)C-H bond functionalisation of 2-pyridyl ethanols upon reaction with alkenes, in the presence of a [RuCl2(arene)](2) catalyst and Cu(OAc)(2) center dot H2O, is performed under mild conditions without additional base. This reaction proceeds via a tandem alcohol dehydrogenation/alkylation with alkenes of the resulting ketone at its a sp(3)C-H bond.