A Conserved Gene Cluster Rules Anaerobic Oxidative Degradation of L-Ornithine

作者：Fonknechten Nuria; Perret Alain^*; Perchat Nadia; Tricot Sabine; Lechaplais Christophe; Vallenet David; Vergne Carine; Zaparucha Anne; Le Paslier Denis; Weissenbach Jean; Salanoubat Marcel

来源：Journal of Bacteriology, 2009, 191(9): 3162-3167.

DOI：10.1128/JB.01777-08

For the ornithine fermentation pathway, described more than 70 years ago, genetic and biochemical information are still incomplete. We present here the experimental identification of the last four missing genes of this metabolic pathway. They encode L-ornithine racemase, (2R,4S)-2,4-diaminopentanoate dehydrogenase, and the two subunits of 2-amino-4-ketopentanoate thiolase. While described only for the Clostridiaceae to date, this pathway is shown to be more widespread.

• 出版日期2009-5
• 单位中国地震局