科研之友
微信
新浪微博
Facebook
分享链接
摘要
Aim: To investigate the correlation between Rap1 GTPase-activating protein (Rap1GAP) expression and clinicopathological outcome in patients with gastric cancer. Methods: A total of 219 patients with gastric cancer who were underwent surgery were enrolled in this study. The expression of Rap1GAP, MMP9, MMP2 and E-cadherin was examined by immunohistochemistry. The data of Rap1GAP expression, clinicopathological characteristics and prognosis were analyzed. Associations between Rap1GAP expression with Helicobacter pylori (Hp), MMP9, MMP2 and E-cadherin were also assessed. Results: The rate of down-regulated expression was present in 64.1% of diffuse type gastric cancer and in 35.5% of intestinal type gastric cancer. Interestingly, the results suggested a significant difference of its expression with histological type. In diffuse type gastric cancer, down-regulated expression of Rap1GAP was significantly correlated with the vascular invasion, histological differentiation, depth of invasion, nodal involvement, advanced tumor-node-metastasis (TNM) stage and poor prognosis. In multivariate analysis, down-regulated expression of Rap1GAP was an independent prognostic factor. Interesting, those statistically significant relationships were not found in intestinal type. Furthermore, Rap1GAP expression was associated with MMP9, MMP2 and E-cadherin with a significant difference. Conclusion: Down-regulated expression of Rap1GAP is present predominantly in diffuse type gastric cancer, not in intestinal type. And, down-regulated expression of Rap1GAP is associated with poor prognosis in diffuse type gastric cancer. Furthermore, down-regulated expression of Rap1GAP may be correlated with epithelial-mesenchymal transition (EMT).
- 出版日期2017
- 单位湖州市中心医院; 浙江大学
