APC licensing and CD4+T cell help in liver-stage malaria

作者：Crispe Ian N^*

来源：Frontiers in Microbiology, 2014, 5: 617.

DOI：10.3389/fmicb.2014.00617

• liver
• hepatocyte
• malaria parasite
• immunity
• CD4+T cell help
• CD8+T cell
• antigen-presenting cells
• licensing

Malaria parasites spend a critical phase of their life cycle inside hepatocytes, in an environment with complex and distinctive immunological features. Here I will discuss how the immunological features of the liver and the adaptations of malaria parasites interact, resulting in defective CD8+ T cell immunity. These processes are explored with a focus on the mechanism by which CD4+ T cells deliver help to CD8+ T cells, and specifically through their interaction with antigen-presenting cells (APCs), resulting in "licensing" of the APCs and enhanced capacity to optimally activate CD8+ T cells. Synthesis of the available evidence supports a model in which the parasite-mediated manipulation of programmed cell death in infected hepatocytes impairs the capacity of the liver's immune system to successfully license APCs and fully activate T cell immunity.

• 出版日期2014-11-11