Agai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose

作者：de Freitas Carvalho Mayara Medeiros; Teixeira Reis Larissa Lelis; Macedo Lopes Juliana Marcia; Lage Nara Nunes; da Costa Guerra Joyce Ferreira; Zago Helena Porto; Bonomo Larissa de Freitas; Pereira Renata Rebeca; de Lima Wanderson Geraldo; Silva Marcelo Eustaquio; Pedrosa Maria Lucia^*

来源：Nutricion Hospitalaria, 2018, 35(2): 318-325.

DOI：10.20960/nh.1294

• Euterpe oleracea Mart
• Fructose-diet
• Hepatic steatosis
• Antioxidant enzymes
• Inflammation

Introduction: the excessive consumption of fructose can cause liver damage, characteristic of non-alcoholic fatty liver disease (NAFLD) associated with changes in lipid metabolism and antioxidant defenses. Agai, the fruit of Euterpe oleracea Mart., has demonstrated numerous biological activities, including anti-inflammatory, antioxidant, and lipid metabolism modulating action.
Objective: we evaluated the benefits of agai supplementation on liver damage caused by replacing starch with fructose in rats.
Methods: thirty male Fischer rats were divided into two groups, the control group (C, 10 animals), which consumed a standard diet (AIN-93M), and the fructose (F, 20 animals) group, which consumed a diet containing 60% of fructose. After eight weeks, 10 animals from the fructose group received 2% of lyophilized agai, and were called the agai fructose group (FA). The animals were fed ad libitum with these diets for another ten weeks. Serum, hepatic and fecal lipid profile, antioxidant enzymes and carbonylated protein were assessed and histopathological characterization of the liver was performed.
Results: agai promoted the reduction of ALT activity in relation to the fructose group (F), reduced alkaline phosphatase to a level similar to that of the control group (C) in relation to the fructose group (F), and reduced catalase activity. The fruit also increased the ratio of total/oxidized glutathione (GSH/GSSG) and reduced the degree of macrovesicular steatosis and the number of inflammatory cells.
Conclusion: the replacement of starch by fructose during this period was effective in promoting NAFLD. Agai showed attenuating effects on some markers of hepatic steatosis and inflammation.

• 出版日期2018-4