Association of Arg72Pro of TP53 and T309G of MDM2 genes polymorphisms with non-small-cell lung cancer in Russians of the Moscow region

作者：Loginov V I^*; Atkarskaya M V; Burdennyy A M; Zavarykina T M; Kazubskaya T P; Nosikov V V; Braga E A; Zhizhina G P

来源：Molecular Biology, 2014, 48(1): 52-57.

DOI：10.1134/S0026893314010099

• Arg72Pro and T309G polymorphic markers
• TP53
• MDM2
• non-small-cell lung cancer
• adeno-carcinoma
• squamous-cell lung carcinoma

Association of TP53 Arg72Pro and MDM2 T309G polymorphic markers with the risk of non-small-cell lung cancer was studied in a Russian population of the Moscow region. The minor Pro/Pro genotype of Arg72Pro and the TG genotype of T309G were associated with non-small-cell lung cancer (OR = 5.46, p = 8 x 10(-6) and OR = 7.38, p = 0.0001, respectively). Both Pro/Pro and TG genotypes were also strongly associated with lung adenocarcinoma (OR = 8.71, p = 3 x 10(-6) and OR = 8.13, p = 0.003, respectively) and squamous-cell lung carcinoma (OR = 4.2, p = 0.001 and OR = 7.02, p = 0.002, respectively). Finally, combined susceptible genotypes of TP53 and MDM2 polymorphisms Arg72Pro and T309G were reliably associated with non-small-cell lung cancer and both its subtypes (OR = 7.9, p = 0.01; OR = 9.12, p = 0.02; OR = 7.31, p = 0.03, respectively).

• 出版日期2014-1