Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms

作者：Lin Yi Tzu; Verma Amanda; Hodgkinson Conrad P^*

来源：Current Genomics, 2012, 13(8): 633-645.

• Atherosclerosis
• Genetic association studies
• Inflammation
• Innate immunity
• Single nucleotide polymorphisms
• Toll-like receptors

Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-associated molecular patterns, are critical for the normal function of the innate immune system. Following their discovery many single nucleotide polymorphisms within TLRs and components of their signaling machinery have been discovered and subsequently implicated in a wide range of human diseases including atherosclerosis, sepsis, asthma, and immunodeficiency. This review discusses the effect of genetic variation on TLR function and how they may precipitate disease.

• 出版日期2012-12