A Nationwide Comparison of Laparoscopic and Open Distal Pancreatectomy for Benign and Malignant Disease

作者：de Rooij Thijs; Jilesen Anneke P; Boerma Djamila; Bonsing Bert A; Bosscha Koop; van Dam Ronald M; van Dieren Susan; Dijkgraaf Marcel G; van Eijck Casper H; Gerhards Michael F; van Goor Harry; van der Harst Erwin; de Hingh Ignace H; Kazemier Geert; Klaase Joost M; Molenaar I Quintus; van Dijkum Els J Nieveen; Patijn Gijs A; van Santvoort Hjalmar C; Scheepers Joris J; van der Schelling George P; Sieders Egbert; Vogel Jantien A; Busch Olivier R

来源：Journal of the American College of Surgeons, 2015, 220(3): 263-U57.

DOI：10.1016/j.jamcollsurg.2014.11.010

BACKGROUND: Cohort studies from expert centers suggest that laparoscopic distal pancreatectomy (LDP) is superior to open distal pancreatectomy (ODP) regarding postoperative morbidity and length of hospital stay. But the generalizability of these findings is unknown because nationwide data on LDP are lacking.
STUDY DESIGN: Adults who had undergone distal pancreatectomy in 17 centers between 2005 and 2013 were analyzed retrospectively. First, all LDPs were compared with all ODPs. Second, groups were matched using a propensity score. Third, the attitudes of pancreatic surgeons toward LDP were surveyed. The primary outcome was major complications (Clavien-Dindo grade >= III).
RESULTS: Among 633 included patients, 64 patients (10%) had undergone LDP and 569 patients (90%) had undergone ODP. Baseline characteristics were comparable, except for previous abdominal surgery and mean tumor size. In the full cohort, LDP was associated with fewer major complications (16% vs 29%; p = 0.02) and a shorter median [interquartile range, IQR] hospital stay (8 days [7-12 days] vs 10 days [8-14 days]; p = 0.03). Of all LDPs, 33% were converted to ODP. Matching succeeded for 63 LDP patients. After matching, the differences in major complications (9 patients [14%] vs 19 patients [30%]; p = 0.06) and median [IQR] length of hospital stay (8 days [7-12 days] vs 10 days [8-14 days]; p = 0.48) were not statistically significant. The survey demonstrated that 85% of surgeons welcomed LDP training.
CONCLUSIONS: Despite nationwide underuse and an impact of selection bias, outcomes of LDP seemed to be at least noninferior to ODP. Specific training is welcomed and could improve both the use and outcomes of LDP.

• 出版日期2015-3