Molecular analysis of carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) as a candidate gene for bovine spongiform encephalopathy susceptibility

作者：Morina R; Knorr C; Haase B; Leeb T; Seuberlich T; Zurbriggen A; Brem G; Schuetz E; Brenig B^*

来源：Animal Genetics, 2010, 41(1): 85-88.

DOI：10.1111/j.1365-2052.2009.01951.x

• bovine spongiform encephalopathy
• BSE
• carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8)
• prion
• transmissible spongiform encephalopathy
• TSE

P>Endogenous prion proteins (PrP) play the central role in the pathogenesis of transmissible spongiform encephalopathies. The carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) promotes the conversion of the cellular PrPC into the pathogenic PrPd. Six sequence variants within the CHST8 gene were identified by comparative sequencing and genotyped for a sample of 623 animals comprising bovine spongiform encephalopathy (BSE)-affected and healthy control cows representing German Fleckvieh (German Simmental), German Holstein (Holstein-Friesian) and Brown Swiss. Significant differences in the allele, genotype and haplotype frequencies between BSE-affected and healthy cows indicate an association of sequence variant g.37254017G > T with the development of the disease in Brown Swiss cattle.

• 出版日期2010-2