科研之友
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摘要
A novel and simple procedure was developed for the construction of fully substituted thiophenes. A series of alpha-haloacetophenone derivatives were converted into fully substituted thiophenes by treatment with sodium sulfide in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene and sodium iodide in aqueous ethanol under aerobic conditions. A mechanism for the reaction is proposed.
- 出版日期2013-4
