A hybrid approach to new molecular scaffolds

作者：Palanichamy Kalanidhi; Kaliappan Krishna P^*

来源：Pure and Applied Chemistry, 2013, 85(6): 1185-1202.

DOI：10.1351/PAC-CON-13-02-08

• hybrid natural products
• natural product synthesis
• new molecular scaffolds
• olefin metathesis
• organic synthesis
• stereocontrolled synthesis
• tandem reactions

Our various efforts toward the synthesis of a set of novel sugar hybrid scaffolds of several biologically active natural products such as taxol, steroids, beta-lactams, and otteliones are presented. We have shown the application of the hybrid approach to design and rapidly generate a library of novel natural product-like compounds, which may have interesting biological features, using metathesis and/or cycloaddition reactions as key steps.

• 出版日期2013-6