A New Fiducial Marker for Gated Radiotherapy in the Lung - A Feasibility Study of Bronchoscopy Based Insertion and Removal in Gottingen Mini-Pig

作者：Carl Jesper^*; Jensen Henrik Kirstein; Nielsen Jane; Nielsen Martin Skovmos; Schmid Markus; Loeschke Siegfried

来源：Scandinavian Journal of Laboratory Animal Science, 2010, 37(2): 117-127.

To develop a new prototype fiducial marker (LS-1) that may be used for gated radiotherapy in the lung. One LS-1 marker was inserted in the lung of each animal under sedation. Animals were kept under observation for four weeks after insertion. After the observation period the marker was removed. Animals were CT scanned after insertion and before removal of the LS-1 marker. After the last CT scan animals were euthanized and lungs excised for pathology.
The LS-1 marker was successfully inserted in all fourteen animals. Thirteen of fourteen LS-1 marker's were in situ after four weeks. Two cases of pneumothorax were seen in connection with insertion. The LS-1 marker could only be successfully removed from eleven of thirteen animals. Damage to the lung was mainly local close to the LS-1 marker insertion site.
The LS-1 marker has the potential to be a fiducial marker suitable for gated external beam radiotherapy in the lung. The method still needs some refinement prior to application in humans.

• 出版日期2010