Multi-institutional retrospective study for the evaluation of ocular function-preservation rates in maxillary sinus squamous cell carcinomas with orbital invasion

作者：Sakashita Tomohiro; Hayashi Ryuichi; Homma Akihiro^*; Matsuura Kazuto; Kato Kengo; Kawabata Kazuyoshi; Monden Nobuya; Hasegawa Yasuhisa; Onitsuka Tetsuro; Fujimoto Yasushi; Iwae Shigemichi; Okami Kenji; Matsuzuka Takashi; Yoshino Kunitoshi; Fujii Masato

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2015, 37(4): 537-542.

DOI：10.1002/hed.23639

• maxillary sinus cancer
• orbital invasion
• ocular function
• squamous cell carcinoma
• chemoradiotherapy

BackgroundThe purpose of this retrospective analysis was to evaluate ocular function and survival rates among treatment modalities in patients with maxillary sinus cancer with orbital invasion.
MethodsEighty-seven patients were classified according to the main treatment modality. Ocular function preservation rates and survival rates were evaluated for each therapeutic modality.
ResultsThe 5-year overall survival rate for the en bloc resection, conservative surgery, superselective intra-arterial chemotherapy, and radiotherapy (RADPLAT), intravenous chemoradiotherapy (IV-CRT) was 70%, 35%, 49%, and 31%, respectively. The ocular function preservation rate for each group was 15%, 27%, 30%, and 17%, respectively. In the en bloc resection group, there was no significant difference in the 5-year overall survival rate between patients with orbital exenteration and those without orbital exenteration (72% vs 71%; p=.9321).
ConclusionThe en bloc resection group showed a favorable survival rate but a low preservation rate. Preservation of orbital contents did not reduce the survival rate.

• 出版日期2015-4
• 单位中国医学科学院肿瘤医院