A Facile Electrochemical Preparation of Reduced Graphene Oxide@Polydopamine Composite: A Novel Electrochemical Sensing Platform for Amperometric Detection of Chlorpromazine

作者：Palanisamy Selvakumar; Thirumalraj Balamurugan; Chen Shen Ming; Wang Yi Ting; Velusamy Vijayalakshmi; Ramaraj Sayee Kannan

来源：Scientific Reports, 2016, 6(1): 33599.

DOI：10.1038/srep33599

We report a novel and sensitive amperometric sensor for chlorpromazine (CPZ) based on reduced graphene oxide (RGO) and polydopamine (PDA) composite modified glassy carbon electrode. The RGO@PDA composite was prepared by electrochemical reduction of graphene oxide (GO) with PDA. The RGO@PDA composite modified electrode shows an excellent electro-oxidation behavior to CPZ when compared with other modified electrodes such as GO, RGO and GO@PDA. Amperometric i-t method was used for the determination of CPZ. Amperometry result shows that the RGO@PDA composite detects CPZ in a linear range from 0.03 to 967.6 mu M. The sensor exhibits a low detection limit of 0.0018 mu M with the analytical sensitivity of 3.63 +/- 0.3 mu A mu M-1 cm(-2). The RGO@PDA composite shows its high selectivity towards CPZ in the presence of potentially interfering drugs such as metronidazole, phenobarbital, chlorpheniramine maleate, pyridoxine and riboflavin. In addition, the fabricated RGO@PDA modified electrode showed an appropriate recovery towards CPZ in the pharmaceutical tablets.

• 出版日期2016-9-21