Methods of screening of gestational diabetes between 24 and 28 weeks'gestation

作者：Virally M^*; Laloi Michelin M

来源：Journal de Gynecologie Obstetrique et Biologie de la Reproduction, 2010, 39(8): S220-S238.

DOI：10.1016/S0368-2315(10)70049-1

• Gestational diabetes mellitus
• Screening
• Oral glucose tolerance test
• Fasting glucose
• Glycosylated haemoglobin

The aim of this review is to answer the question "how to detect the gestational diabetes mellitus (GDM) between 24 and 28 weeks of gestation?" Two approaches are well established one step approach (75g OGTT) and two steps approach (50g followed 100g OGTT) The analysis of the literature shows that each of these methods has a good reproducibility close to 80 %, without requiring preliminary dietetics The HAPO study provides consistent data about the 75g OGTT materno foetal morbidity related Furthermore, the one step approach, relationship two steps approach, has several advantages reduction of time of diagnosis and primary care, better tolerance, simpler memorization We recommend for the screening and the diagnosis of GDM an 75g OGTT with three measures FPG, 1 h and 2 h The various alternative methods are discussed The measure of the fasting blood glucose isolated between 24 and 28 weeks of gestation is not a relevant approach None of the other alternative methods (HbA1c, fructosamine, glycosuria, random and postprandial plasma glucose) cannot be recommended Indeed, these methods have been addressed in little numerous studies, among heterog

• 出版日期2010-12