Do Substantia Nigra Dopaminergic Neurons Differentiate Between Reward and Punishment?

作者:Frank Michael J; Surmeier D James*
来源:Journal of Molecular Cell Biology, 2009, 1(1): 15-16.
DOI:10.1093/jmcb/mjp010

摘要

The activity of dopaminergic neurons are thought to be increased by stimuli that predict reward and decreased by stimuli that predict aversive outcomes. Recent work by Matsumoto and Hikosaka challenges this model by asserting that stimuli associated with either rewarding or aversive outcomes increase the activity of dopaminergic neurons in the substantia nigra pars compacta.