Antitumor Agents. 282. 2 '-(R)-O-Acetylglaucarubinone, a Quassinoid from Odyendyea gabonensis As a Potential Anti-Breast and Anti-Ovarian Cancer Agent

作者：Usami Yoshihide; Nakagawa Goto Kyoko; Lang Jing Yu; Kim Yoon; Lai Chin Yu; Goto Masuo; Sakurai Nobuko; Taniguchi Masahiko; Akiyama Toshiyuki; Morris Natschke Susan L; Bastow Kenneth F; Cragg Gordon; Newman David J; Fujitake Mihoyo; Takeya Koichi; Hung Mien Chic; Lee Eva Y H P; Lee Kuo Hsiung^*

来源：Journal of Natural Products, 2010, 73(9): 1553-1558.

DOI：10.1021/np100406d

A new quassinoid, designated 2'-(R)-O-acetylglaucarubinone (1), and seven known quassinoids (2-8) were isolated, using bioactivity-guided separation, from the bark of Odyendyea gabonensis (Pierre) Engler [syn. Quassia gabonensis Pierre]. The structure of 1 was determined by spectroscopic analysis and by semisynthesis from glaucarubolone. Complete (1)H and (13)C NMR assignments of compounds 1-8 were also established from detailed analysis of two-dimensional NMR spectra, and the reported configurations in odyendene (7) and odyendane (8) were corrected. Compound 1 showed potent cytotoxicity against multiple cancer cell lines. Further investigation using various types of breast and ovarian cancer cell lines suggested that 1 does not target the estrogen receptor or progesterone receptor. When tested against mammary epithelial proliferation in vivo using a Brcal/p53-deficient mice model, 1 also caused significant reduction in mammary duct branching.

• 出版日期2010-9
• 单位中国医科大学