A Novel Atenolol Sensor Based on Polypyrrole Electrode and Using Differential Pulse Voltammetry

作者：Ebrahim Shaker^*; Soliman Moataz; Sadik Wagih; Said Mohamed

来源：Sensor Letters, 2011, 9(4): 1423-1429.

DOI：10.1166/sl.2011.1701

• Conducting Polymer
• Polypyrrole
• Atenolol
• Biosensor

The electrooxidation of atenolol (ATN) has been studied at 2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt (AMPSNa) doped PPy electrode in 1 M phosphate buffer by using deferential pulse voltammetry technique. Polypyrrole-AMPSNa electrode prepared using galvanostatic technique has been found to exhibit an excellent electrocatalytic activity towards atenolol oxidation. Characterization of the polypyrrole-AMPSNa was carried out using infrared spectra, scanning electron microscope, X-ray diffraction and cyclic voltammetry. It is found that AMPSNa doped PPy film is a polycrystalline material with cauliflower morphology. A well-defined oxidation peak has been observed at -789.7 mV versus Ag/AgCl electrode for atenolol oxidation. The plotting of maximum peak currents versus concentration of ATN was linear with a good fitting in the range from 1 x 10(-9) M to 8 x 10(-9) M. The minimum detection limit fop AMPSNa doped PPy electrode was found to be 1 x 10(-9) M ATN. This method was successfully applied to determine the atenolol concentration in the nano-range in a pharmaceutical tablet.

• 出版日期2011-8