Four new dammarane-type triterpenes derivatives from hydrolyzate of total Gynostemma pentaphyllum saponins and their bioactivities

作者：Zhang, Xiaoshu; Shi, Guohui; Liu, Mingbing; Chen, Rong; Wu, Xiaojun; Zhao, Yuqing^*

来源：Natural Product Research, 2019, 33(11): 1605-1611.

DOI：10.1080/14786419.2018.1428592

• Gynostemma pentaphyllum
• anti-hepatic fibrosis
• Cardiomyocytes oxidative injury

Phytochemical investigation of hydrolysate of total G. pentaphyllum saponins led to the isolation of four novel triterpenes, Gypensapogenin U (1), Gypensapogenin V (2), Gypensapogenin W (3) and Gypensapogenin X (4). The structures of these compounds were identified by 1D, 2D-NMR and HR-ESI-MS evidences. Additionally, the protective activity of these new compounds against cardiomyocytes injury induced by H2O2 and their cytotoxic activity against t-HSC/Cl-6 cells were evaluated. @@@ [GRAPHICS] @@@ .

• 出版日期2019-6-3
• 单位沈阳药科大学