科研之友
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摘要
A kind of X-ray computed tomography (CT)/fluorescence dual-modal nanoemulsion probe that combined both CT imaging and near-infrared fluorescent (NIRF) imaging abilities was developed for application in tumor diagnosis. In this study, NIRF molecule indocyanine green (ICG-Der-01), a kind of hydrophobic dye, was encapsulated in clinic CT contrast agent of iodinated oil injection based on oil-in-water nanoemulsion platform. The obtained ICG-iodinated oil nanoemulsion exhibited excellent CT and fluorescence capabilities. In vitro studies revealed that this nanoemulsion could serve as an effective dual-modal probe by Micro-CT and confocal microscopy imaging of murine macrophage cells and mouse breast tumor cells without obvious cytotoxicity. Then in vivo clinical CT and NIRF imaging results suggested the nanoemulsion could accumulate in tumor by the enhanced permeation and retention (EPR) effect and visualize tumor tissues in living body. All these results demonstrated the ICG-iodinated oil nanoemulsion had great potential in tumor diagnosis by dual-modal CT/fluorescence imaging in future.
