An antioxidant, N,N%26apos;-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test

作者：Matsumoto Mariko; Yamaguchi Makiko; Yoshida Yuka; Senuma Mika; Takashima Hiromasa; Kawamura Tomoko; Kato Hina; Takahashi Mika; Hirata Koizumi Mutsuko; Ono Atsushi; Yokoyama Kazuhito; Hirose Akihiko^*

来源：Food and Chemical Toxicology, 2013, 56: 290-296.

DOI：10.1016/j.fct.2013.02.029

• N,N%26apos
• -diphenyl-p-phenylenediamine
• Prostaglandin
• Repeated dose toxicity
• Reproductive toxicity
• Gestation period

A 28-day repeated dose toxicity test and reproduction/developmental toxicity test for N,N%26apos;-diphenyl-p-phenylenediamine (DPPD) were conducted in [Crl:CD(SD)] SPF rats. Male and female rats were dosed with DPPD by gavage for 28 days at 0, 100, 300, or 1000 mg/kg bw/day or for a total of 42-46 days at 0, 8, 50, or 300 mg/kg bw/day. No significant adverse effects were observed in the repeated dose toxicity study up to 1000 mg/kg bw/day in both sexes. In the reproduction/developmental toxicity study, two females showed piloerection, hypothermia, and pale skin; one died and the other showed dystocia on day 23 of pregnancy at 300 mg/kg bw/day. Another female delivered only three live pups at 300 mg/kg bw/day. A significantly prolonged gestation period was observed at 50 and 300 mg/kg bw/day. The NOAELs of repeated dose toxicity and reproduction/developmental toxicity were considered to be 1000 and 8 mg/kg bw/day, respectively.

• 出版日期2013-6