[1-8-N alpha C]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum

作者：Beirigo Pamela J dos S; Torquato Heron F V; dos Santos Carlos H C; de Carvalho Mario G; Castro Rosane N; Paredes Gamero Edgar J; de Sousa Paulo T Jr; Jacinto Marcos J; da Silva Virginia C

来源：Journal of Natural Products, 2016, 79(5): 1454-1458.

DOI：10.1021/acs.jnatprod.5b00177

A new orbitide named [1-8-N alpha C]-zanriorb A1 (1) was isolated and characterized from the leaves of Zanthoxylum riedelianum using NMR and mass spectrometry. The absolute configuration of the amino acids was determined using Marfey's method on the acid hydrolysates. Compound 1 induced cell death by apoptosis in Jurkat leukemia T cells (IC50 218 nM).

• 出版日期2016-5