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摘要
An enantioselective formal thio [3 + 3] spiroannulation reaction of indoline-2-thiones to 1-azadienes has been developed by the use of a quinine-derived bifunctional tertiary amine-thiourea catalyst, which furnished a series of optically active spiro [thiopyranoindole-benzoisothiazole] heterocycles with a Spiro quaternary C-N/C-S stereogenic centers in high yields with good to excellent diastereo- and enantioselectivities.
- 出版日期2015-9-4
- 单位苏州大学
