Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults

作者：Ponomareva Natalya V^*; Goltsov Andrey Y; Kunijeva Svetlana S; Scheglova Nadejda S; Malina Daria D; Mitrofanov Andrey A; Boikova Tatiana I; Rogaev Evgeny I

来源：Neurobiology of Aging, 2012, 33(4): 839.e11.

DOI：10.1016/j.neurobiolaging.2011.11.013

• EEG
• Apolipoprotein E
• Hyperventilation
• Hypocapnia
• Oxidative stress
• Alzheimer%26apos
• s disease
• Cerebrovascular disease
• Aging

The epsilon4 allele of the apolipoprotein E gene (ApoE), as well as aging increase the risk of Alzheimer%26apos;s and vascular diseases. Electroencephalogram (EEG) reactivity to hyperventilation (HV) depends on hypocapnia-induced cerebral vasoconstriction, which may be impaired in subjects with subclinical cerebrovascular disease. Quantitative EEG at rest and under 3-minute HV was examined in 125 healthy subjects divided into younger (age range 28-50) and older (age range 51-82) cohorts and stratified by ApoE genotype. The younger ApoE-epsilon4 carriers had excessive EEG reactivity to HV characterized by the manifestation of high-voltage delta, theta activity and sharp waves, and larger HV-induced changes in EEG relative powers than in the younger ApoE-epsilon4 noncarriers. EEG reactivity to HV decreased with aging, and in the ApoE-epsilon4 carriers the decrease was more pronounced than in the ApoE-epsilon4 noncarriers. The older ApoE-epsilon4 carriers had smaller HV-induced changes in EEG relative powers than the older ApoE-epsilon4 noncarriers. A marked decline of EEG reactivity to HV in the older ApoE-epsilon4 carriers suggests the possible impact of vascular factors on the pathogenesis of ApoE-induced Alzheimer disease.

• 出版日期2012-4