A liquid calcium+vitamin D-3 supplement is effective prophylaxis against hypocalcemic toxicity during apheresis platelet donation

作者：Weinstein Robert^*; Haynes Stefanie; Zhao Yong; Hickson Elda; Linden Jeanne; Pierre Patricia St; Ducharme Paula; Sulmasy Paula; Graves Molly; Bailey Jeffrey A; Welch Linda; Simard Amie; Vauthrin Michelle; Greene Mindy

来源：Journal of Clinical Apheresis, 2018, 33(1): 60-64.

DOI：10.1002/jca.21565

• blood donor
• paresthesia
• plateletpheresis
• side effects

Hypocalcemic toxicity, because of return of citrate anion to the donor, is the major toxicity of apheresis platelet donation. Oral calcium carbonate, given prophylactically at the start of donation, has shown limited ability to alleviate this toxicity. We examined whether repeated prophylactic doses of calcium carbonate, or of a liquid preparation containing calcium citrate, calcium phosphate, and vitamin D-3, would be more effective at preventing symptoms of hypocalcemic toxicity. Symptoms were reported by 48% of donors who received no prophylaxis and 60% of donors who received 1000 mg of oral calcium carbonate at the start of, and every 20 minutes during, donation (P = 0.711). Only 19.2% of donors who received the liquid preparation (1000 mg calcium, 1000 IU vitamin D-3) reported symptoms (P = 0.040 versus no prophylaxis, P = 0.039 versus calcium carbonate). This difference was not because of gender, weight, age, or blood volume of the donor. Neither calcium preparation prevented a measurable fall in plasma ionized calcium during donation. We conclude that liquid calcium citrate/calcium phosphate/vitamin D-3 provides effective prophylaxis against hypocalcemic toxicity during platelet donation, however it does not prevent a fall in plasma ionized calcium.

• 出版日期2018-2