Approaches for the development of solid and semi-solid lipid-based formulations

作者：Jannin V^*; Musakhanian J; Marchaud D

来源：Advanced Drug Delivery Reviews, 2008, 60(6): 734-746.

DOI：10.1016/j.addr.2007.09.006

• bioavailability enhancement
• excipient
• formulation
• lipid-based drug delivery systems
• process
• technology

Interest in Lipid Based Drug Delivery (LBDD) has developed over the past decade fuelled by a better understanding of the multiple roles lipids may play in enhancing oral bioavailability. Moreover, the emergence of novel excipients with acceptable regulatory and safety profiles coupled with advances in formulation technologies have greatly improved the potential for successful lipid based formulations. With the growing interest in this field, there is an increasing need for guidelines in excipient selection and characterization; material handling, formulation design, and processing techniques to obtain effective and patient-compliant dosage forms. The aim of this review is to present the recent approaches in selecting the most appropriate lipid system(s); methods for characterization of their behavior in vitro and in vivo; and the current formulation and processing techniques to obtain various solid dosage forms.

• 出版日期2008-3-17