Dequalinium induces human leukemia cell death by affecting the redox balance

作者：Garcia Perez Ana I^*; Galeano Eva; Nieto Elena; Sancho Pilar

来源：Leukemia Research, 2011, 35(10): 1395-1401.

DOI：10.1016/j.leukres.2011.03.012

• DQAsomes
• Dequalinium
• Antitumoral
• Leukemia
• Apoptosis
• Glutathione
• JNK
• p38

Dequalinium, an amphiphilic quinolinium derivative, selectively accumulates in mitochondria and displays anticancer activity in cells from different malignancies. Previous studies indicate a differential DQA-induced cytotoxicity in NB4 and K562 human leukemia cells as a consequence of an early disturbance in mitochondrial function. Results in this paper show that DQA induces a concentration-dependent oxidative stress by decreasing GSH level and increasing ROS in a cell type specific way. Inhibitors of the JNK and p38 stress regulated kinases potentiate DQA-induced NB4 cell death suggesting a protective function for these enzymes. K562 cells with relatively high GSH levels remained resistant to DQA action.

• 出版日期2011-10