A combined prognostic factor for improved risk stratification of patients with oral cancer

作者：Kim, K-Y; Zhang, X.; Kim, S-M; Lee, B-D; Cha, I-H^*

来源：Oral Diseases, 2017, 23(1): 91-96.

DOI：10.1111/odi.12579

• combined prognostic factor
• risk stratification
• oral cancer
• lymph node ratio
• clinical diagnosis

PurposeWe aimed to identify a combined prognostic factor for predicting better performance in risk stratification.
Materials and MethodsWe reviewed the clinical and pathological variables of 316 patients with oral squamous cell carcinoma (OSCC) who underwent surgery. To identify a combined predictor, principal component analysis (PCA) was performed.
ResultsUnivariate analysis showed that the independent prognostic variables for overall survival (OS) were pathologic T stage (T1 vs T4, HR=1.99, 95% CI:=1.083-3.675, P=0.026) and pathologic N stage (N0 vs N2, HR=1.90, 95% CI:=1.17-3.08, P=0.008). In the multivariate analysis, only pathologic T stage was significant (P=0.006 and P=0.007); however, the multivariate model was not significant (P=0.191). The multivariate model became significant by including lymph node ratio (LNR) instead of pathologic N stage (P=0.0025 in numeric LNR, P=0.0007 in categorized LNR). Also, the performance of prediction model was improved by a combined prognostic factor (P=0.0002).
ConclusionsThe newly identified combined prognostic factor included resection margin, differentiation, and LNR, and they were insignificant factors independently except for LNR. This combined prognostic factor showed a good performance although it did not include molecular markers; therefore, it may be used conveniently for risk stratification of patients with OSCC by combining only clinical information.

• 出版日期2017-1
• 单位延边大学