Acid-sensing ion channel 1: A novel therapeutic target for migraine with aura

作者：Holland Philip R; Akerman Simon; Andreou Anna P; Karsan Nazia; Wemmie John A; Goad**y Peter J^*

来源：Annals of Neurology, 2012, 72(4): 559-563.

DOI：10.1002/ana.23653

Objective: Migraine with aura is a severe debilitating neurological disorder with few relatively specific therapeutic options. %26lt;br%26gt;Methods: We used amiloride, a blocker of epithelial sodium channels, to evaluate its pharmacological potential and explored the biology of a potential mechanism of action in well-established experimental models. %26lt;br%26gt;Results: Amiloride was shown to block cortical spreading depression, the experimental correlate of aura, and inhibited trigeminal activation in in vivo migraine models, via an acid-sensing ion channel 1 mechanism. Remarkably, amiloride then demonstrated good clinical efficacy in a small open-labeled pilot study of patients, reducing aura and headache symptoms in 4 of 7 patients with otherwise intractable aura. %26lt;br%26gt;Interpretation: The observations here identify an entirely novel treatment strategy for migraine. ANN NEUROL 2012;72:559563

• 出版日期2012-10