科研之友
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摘要
Background: Let-7f has been confirmed to express in different malignant human tumors, it usually participates in tumor progression and development by different target factors. However, the studies about the association between let-7f and glioma are limited. The aim of this study was to evaluate the potential value of let-7f as a bio-marker in the prognosis of glioma. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of let-7f in 136 glioma tissues and 25 normal specimens. Peristin expression was evaluated by western blotting. The relationship between let-7f expression and clinical factors was analyzed by chi-square test. And Kaplan-Meier and Cox regression analysis was used to estimate the prognostic value of let-7f. Results: The let-7f expression was remarkably down-regulated in glioma tissues compared with normal brain tissues (P<0.001), and let-7f expression in patients with low WHO grade was significantly higher than that with high grade. The expression of periostin was decreased in patients with glioma compared to normal controls. And the expression of let-7f was significantly related to tumor size and WHO grade. Kaplan-Meier analysis suggested that patients with low let-7f expression had a worse overall survival than those with high let-7f expression (P<0.001). Multivariate analysis indicated let-7f could act as an independent prognostic biomarker for patients with glioma. Conclusions: Let-7f acted as a tumor suppressor and participated in the development and progression of glioma. Besides, it could be a valuable prognostic bio-marker in patients with glioma.
- 出版日期2017
- 单位苏州大学
